Innate immunity and vaccine
نویسندگان
چکیده
منابع مشابه
Innate Immunity Plays a Key Role in Leishmania Infection: Implications for Vaccine Design
Neutrophils are part of the first line of immune response and are essential for resistance against a variety of pathogens. They professionally mediate direct killing of pathogens, recruit other phagocytes by specific chemokines, produce cytokines and interact with different immune cells to shape the adaptive response. Leishmania as an obligatory intracellular parasite has evolved to benefit thi...
متن کاملFactors influencing innate immunity and vaccine responses in infancy.
Despite significant progress in reducing the burden of mortality in children under the age of five, reducing mortality in newborns remains a major challenge. Infection plays a significant role in infant deaths and interventions such as early vaccination or antenatal immunization could make a significant contribution to prevention of such deaths. In the last few years, we have gained new insight...
متن کاملTranslating Innate Immunity into Immunological Memory: Implications for Vaccine Development
Vaccination is the most effective means of preventing infectious diseases. Despite the success of many vaccines, there is presently little knowledge of the immunological mechanisms that mediate their efficacy. Such information will be critical in the design of future vaccines against old and new infectious diseases. Recent advances in immunology are beginning to provide an intellectual framewor...
متن کاملBeyond Empiricism: Informing Vaccine Development through Innate Immunity Research
Although a great public heath success, vaccines provide suboptimal protection in some patient populations and are not available to protect against many infectious diseases. Insights from innate immunity research have led to a better understanding of how existing vaccines work and have informed vaccine development. New adjuvants and delivery systems are being designed based upon their capacity t...
متن کاملA trail blazed through DNA vaccine, noninvasive vaccine, and innate-adaptive immunity duo
I entered the field of vaccinology when I joined Dr. Stephen Johnston’s laboratory as a postdoc in 1990. He and Dr. John Sanford co-designed and fabricated the first hand-held gene gun and my job was to transfect live animals by delivering DNA-coated gold particles into a restricted subset of tissues under the gun point. After bombarding a recombinant plasmid encoding a human protein into the o...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2010
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2010.09.023